Diving into the effects of niacinamide
What exactly is niacinamide?
Niacinamide, which is also called nicotinamide, is one of two major forms of vitamin B3 (niacin) found in supplements (the other is nicotinic acid). It’s often touted to help manage acne, rosacea, pigmentation issues, and wrinkles.
Niacinamide/nicotinamide may be effective because it’s a precursor to two important biochemical cofactors: nicotinamide adenine dinucleotide (NAD+/NADH) and nicotinamide adenine dinucleotide phosphate (NADP+). Both of these molecules are central to the chemical reactions that your cells need to repair damage, propagate, and function normally, and also allows your body to absorb and neutralize free radicals.
Interestingly, the same process—helping your body create more NAD+ and, therefore, repair damage—is thought to be the root of both topical and oral benefits derived from niacinamide on the skin. There’s also evidence that topical niacinamide can increase the production of ceramides (lipids that help maintain the skin’s protective barrier), which may contribute to its topical effects on wrinkles, fine lines, and the skin’s moisture barrier. All of this is probably why you’re seeing niacinamide listed in a lot of skin-care products.
What can niacinamide actually do for you?
Acne, rosacea, and other inflammatory skin conditions:
Niacinamide’s anti-inflammatory properties make it an attractive treatment for skin conditions marked by inflammation, like acne. In fact, in two double-blind studies—one published in 2013 and the other published in 1995, both in the International Journal of Dermatology—a topical preparation of 4 percent niacinamide treated moderate acne just as well as topical antibiotics commonly prescribed to acne patients when applied twice daily for eight weeks.
Other research suggests that a 2 percent topical niacinamide may also inhibit the production of oil, which could be beneficial to people dealing with acne. Plus, both dermatologists we talked to say that niacinamide is relatively nonirritating compared to other acne treatments, making it an especially attractive option for people with dry or sensitive skin.
In addition to topical preparations, oral niacinamide supplements have been shown to reduce inflammation associated with mild to moderate rosacea and acne, particularly when oral antibiotics aren’t an option.
There is also limited evidence that topical niacinamide can help repair the function of the stratum corneum, the protective outer layer of skin, which may add to its anti-inflammatory effects.
Pigmentation issues, fine lines, and wrinkles:
There are very few clinical studies on the effects of niacinamide on fine lines and wrinkles, so the evidence we have is somewhat sparse. But there are a few studies. For instance, in one study published in 2004 in the International Journal of Cosmetic Science, researchers had 50 women (all white and between the ages of 40 and 60) apply a moisturizer containing 5 percent niacinamide to one half of their face and a placebo moisturizer to the other half for 12 weeks. Their results showed that the halves of their faces receiving niacinamide had significant improvements in hyperpigmentation spots, fine lines, and wrinkles compared to the control side.
Another split-face study, this one published in 2011 in Dermatology Research and Practice, found that a topical 4 percent niacinamide treatment was less effective than 4 percent hydroquinone (usually considered the gold standard) for treating melasma over eight weeks in 27 participants. Specifically, 44 percent of patients saw good-to-excellent improvement with niacinamide and 55 percent saw the same with hydroquinone. So, the niacinamide wasn’t totally ineffective—and it came with fewer side effects (present in 18 percent of participants) than the hydroquinone (present in 29 percent).
Here’s how to get started with niacinamide.
Adding topical niacinamide to your skin-care routine is simple and low risk: Buy a product that contains it, and apply as directed. Some people experience some mild irritation, which will likely go away with repeated use. (If it doesn’t, or you have any questions about what kind of side effects you’re experiencing, definitely check in with your derm to make sure you don’t end up with something more serious.)
Most major studies used topical preparations containing 2 percent to 10 percent niacinamide, so look for a product in that range if you can. Those who are looking for a moisturizer with niacinamide may want to check out our Pure molecular serum moisturiser, or our Illume Brightening Peptide Moisturizer for a combination of Niacinamide and Peptide. There's also a plethora of option in our TAHNYC collection., it would definitely ba good idea to check it out.